Addicted to Homer?
نویسنده
چکیده
منابع مشابه
Homer2 and Alcohol: A Mutual Interaction
The past two decades of data derived from addicted individuals and preclinical animal models of addiction implicate a role for the excitatory glutamatergic transmission within the mesolimbic structures in alcoholism. The cellular localization of the glutamatergic receptor subtypes, as well as their signaling efficiency and function, are highly dependent upon discrete functional constituents of ...
متن کاملAssessing the operational robustness of the HOMER model for Marine Corps use in expeditionary environments
As the Marine Corps pursues greater energy efficiency in expeditionary operations, the HOMER micropower optimization model provides potential to serve as a powerful tool for improving Marine Corps power planning. The HOMER software was developed for the modeling and simulation of micropower systems over long periods of time. Although a deterministic model, HOMER uses stochastic input data, spec...
متن کاملTransition of Homer isoforms during skeletal muscle regeneration.
Homer represents a new and diversified family of proteins that includes several isoforms, Homer 1, 2, and 3; some of these isoforms have been reported to be present in striated muscles. In this study, the presence of Homer isoforms 1a, 1b/c/d, 2b, and 3 was thoroughly investigated in rat skeletal muscles under resting conditions. Transition in Homer isoforms compositon was studied under experim...
متن کاملMice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity.
Transient receptor potential (TRP) channels are nonselective cation channels, several of which are expressed in striated muscle. Because the scaffolding protein Homer 1 has been implicated in TRP channel regulation, we hypothesized that Homer proteins play a significant role in skeletal muscle function. Mice lacking Homer 1 exhibited a myopathy characterized by decreased muscle fiber cross-sect...
متن کاملHomer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channels.
Group I metabotropic glutamate receptors (mGluR1 and 5) couple to intracellular calcium pools by a family of proteins, termed Homer, that cross-link the receptor to inositol trisphosphate receptors. mGluRs also couple to membrane ion channels via G-proteins. The role of Homer proteins in channel modulation was investigated by expressing mGluRs and various forms of Homer in rat superior cervical...
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ورودعنوان ژورنال:
- The Journal of neuroscience : the official journal of the Society for Neuroscience
دوره 25 42 شماره
صفحات -
تاریخ انتشار 2005